Wayne Kramer, co-founder of the influential protopunk Detroit band MC5, known for their hardcore anthems like "Kick Out the Jams" and credited with influencing bands such as The Clash and Rage Against the Machine, has passed away at the age of 75.

Kramer passed away on Friday (Feb. 2) at Cedars-Sinai hospital in Los Angeles, as confirmed by Jason Heath, a dear friend and executive director of Kramer's nonprofit organization, Jail Guitar Doors.

Heath stated that the cause of death was pancreatic cancer.

During the late 1960s to early 1970s, no band epitomized the revolutionary ethos of the era quite like the MC5, comprising Kramer, Fred “Sonic” Smith on guitars, Rob Tyner on vocals, Michael Davis on bass, and Dennis “Machine Gun” Thompson on drums.

Under the management of White Panther co-founder John Sinclair for a period, they gained renown for their unfiltered, uncompromising music, which they envisioned as the soundtrack for the impending uprising.

"Brother Wayne Kramer was the finest individual I've ever had the privilege to know," expressed Rage Against the Machine guitarist Tom Morello in a post on Instagram on Friday.

"He embodied a unique blend of profound wisdom, deep compassion, remarkable empathy, and unwavering conviction. His band, the MC5, essentially pioneered punk rock music," Morello remarked.

While the band experienced limited commercial success and its original lineup disbanded in the early 1970s, its legacy persevered, celebrated for its distinctive sound and its fusion of music with political activism.

Kramer, who had a tumultuous history marked by legal disputes and struggles with substance abuse, recounted his journey in the 2018 memoir "The Hard Stuff: Dope, Crime, the MC5, and My Life of Impossibilities."

Kramer and Smith had been acquainted since their teenage years and collaborated with different musicians in the Detroit area before solidifying the core lineup in the mid-1960s.